Suppose we want to design a new placebo-controlled trial to evaluate an experimental medication
Suppose we want
to design a new placebo-controlled trial to evaluate an experimental
medication to increase lung capacity. The primary outcome is peak
expiratory flow rate, a continuous variable measured in liters per
minute. The primary outcome will be measured after 6 months of
treatment. The mean peak expiratory flow rate in adults is 300 with a
standard deviation of 50. How many subjects should be enrolled to ensure
80% power to detect a difference of 15 liters per minute with a
two-sided test and a = 0.05?
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